Human Lactoferrin

$170.00

Catalog Number: PL50012

Product Size: 200 ug

Catalog Number. PL50012 Categories: , Tag:

Additional information

Entrez Gene

4057

Associated Disease

Cancer, Crohn's Disease., Infectious Diarrhea, Inflammatory Bowel Disease, Pouchitis

Species

Human

UniProt

P02788

Protein Detail Express

Lactoferrin purified from human milk

Purity

>96% by SDS-PAGE

Presentation

Lyophilized from PBS pH 7.4 with 5% Treharose

MW

82 kDa

Storage

-20°C or below

Documentation

    Publications (63 results)

    Please use discretion when following external links; Assaypro cannot guarantee the validity and security of all citation links provided.

    Immunomodulatory effect of human lactoferrin on toll-like receptors 2 expression as therapeutic approach for keratoconus

    • https://www.mdpi.com/1422-0067/23/20/12350
    • U Regueiro, M López-López… - International Journal of …, 2022 - mdpi.com
    • Keratoconus (KC) is a corneal disorder whose etiology shares a close relationship with Lactoferrin (LTF) dysregulation and Toll-like Receptors 2 (TLR2) overexpression. This study …

    Albumin fusion at the N-terminus or C-terminus of human lactoferrin leads to improved pharmacokinetics and anti-proliferative effects on cancer cell lines

    • https://www.sciencedirect.com/science/article/pii/S0928098720303390
    • K Ueda, M Shimizu, A Ohashi, D Murata… - European Journal of …, 2020 - Elsevier
    • … Human lactoferrin (hLF), a soluble factor of the innate immune system, exhibits various biological functions and therefore has potential as a therapeutic protein. However, the clinical …

    Separation of lactoferrin from human saliva using monolithic disc

    • https://link.springer.com/article/10.1007/s10337-013-2459-x
    • O Zitka, S Skalickova, S Krizkova, M Vlkova, V Adam… - Chromatographia, 2013 - Springer
    • In this study, we optimized method for the isolation and detection of lactoferrin from human saliva using 3 mm short monolithic disc. We optimized the conditions for separation as flow …

    Breast milk and saliva lactoferrin levels and postnatal cytomegalovirus infection

    The influence of lactoferrin in plasma and peritoneal fluid on iron metabolism in women with endometriosis

    • https://www.mdpi.com/1422-0067/24/2/1619
    • E Skarżyńska, M Wróbel, H Zborowska… - International journal of …, 2023 - mdpi.com
    • The aim of this study was to investigate the relationship between lactoferrin and iron and its binding proteins in women with endometriosis by simultaneously measuring these …

    Variable concentration of ferritin in meconium in relation to the iron regulatory proteins and newborn body size

    Relationship between salivary immunoglobulin a, lactoferrin and lysozyme flow rates and lifestyle factors in Japanese children: a cross-sectional study

    • https://www.tandfonline.com/doi/abs/10.1080/00016357.2016.1223340
    • M Ide, J Saruta, M To, Y Yamamoto… - Acta Odontologica …, 2016 - Taylor & Francis
    • … Human Lactoferrin ELISA Kit (Assaypro LLC, St. Charles, MO). Briefly, sample and human lactoferrin standards (Assaypro … of biotinylated anti-human lactoferrin antibody to each well …

    Hinge-deficient IgG1 Fc fusion: Application to human lactoferrin

    • https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.7b00221
    • Y Shiga, D Murata, A Sugimoto, Y Oshima… - Molecular …, 2017 - ACS Publications
    • … In our previous study, we generated a recombinant human lactoferrin (hLF)-immunoglobulin G1 Fc fusion protein (hLF-hinge-CH2-CH3) with improved stability, biological activity, and …

    Optimized lactoferrin as a highly promising treatment for intracerebral hemorrhage: pre-clinical experience

    • https://journals.sagepub.com/doi/abs/10.1177/0271678X20925667
    • X Zhao, M Kruzel, SM Ting, G Sun… - Journal of Cerebral …, 2021 - journals.sagepub.com
    • … Plasma samples were assayed for hLTF using an AssayPro human LTF ELISA Kit (catalog # EL2011-1) according to the manufacturer’s protocol. Rat LTF did not cross-react with the …

    Antidiabetic efficacy of lactoferrin in type 2 diabetic pediatrics; controlling impact on PPAR-γ, SIRT-1, and TLR4 downstream signaling pathway

    • https://link.springer.com/article/10.1186/s13098-018-0390-x
    • WA Mohamed, MF Schaalan - Diabetology & metabolic syndrome, 2018 - Springer
    • … Plasma Lf concentration was assessed in plasma using an ELISA kit (Assaypro EL2011-1, St.-Charles, USA) that is highly specific to human Lactoferrin. This assay employed a …

    Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin

    • https://cdnsciencepub.com/doi/abs/10.1139/bcb-2020-0238
    • HL Itell, A Berenz, RJ Mangan… - … and Cell Biology, 2021 - cdnsciencepub.com
    • Lactoferrin supplementation may help prevent infections in preterm infants, but the efficacy has varied with different doses and products. We assessed the absorption and excretion of …

    Randomized controlled trial of bovine lactoferrin for prevention of sepsis and neurodevelopment impairment in infants weighing less than 2000 grams

    • https://www.sciencedirect.com/science/article/pii/S0022347619317172
    • TJ Ochoa, J Zegarra, S Bellomo, CP Carcamo… - The Journal of …, 2020 - Elsevier
    • Objectives To determine the effect of bovine lactoferrin on prevention of late-onset sepsis (LOS) and neurodevelopment delay. Study design Randomized, double-blind, controlled trial …

    Variations in serum concentrations of C-reactive protein, ceruloplasmin, lactoferrin and myeloperoxidase and their interactions during normal human pregnancy and …

    Recombinant human lactoferrin-Fc fusion with an improved plasma half-life

    • https://www.sciencedirect.com/science/article/pii/S0928098714004333
    • Y Shiga, Y Oshima, Y Kojima, A Sugimoto… - European Journal of …, 2015 - Elsevier
    • Lactoferrin (LF), an 80-kDa iron-binding glycoprotein found in mammalian exocrine secretions, has potential therapeutic efficacy due to its extensive health-promoting effects. However, …

    Meconium proteins involved in iron metabolism

    • https://www.mdpi.com/1422-0067/25/13/6948
    • E Skarżyńska, A Jakimiuk, T Issat… - International Journal of …, 2024 - mdpi.com
    • The lack of specific biological materials and biomarkers limits our knowledge of the mechanisms underlying intrauterine regulation of iron supply to the fetus. Determining the meconium …

    Supplementation of infant formulas with recombinant human lactoferrin and/or galactooligosaccharides increases iron bioaccessibility as measured by ferritin formed …

    Lactoferrin–endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes

    Lactoferrin conjugated iron oxide nanoparticles for targeting brain glioma cells in magnetic particle imaging

    • https://pubs.rsc.org/en/content/articlehtml/2015/nr/c5nr02831k
    • A Tomitaka, H Arami, S Gandhi, KM Krishnan - Nanoscale, 2015 - pubs.rsc.org
    • … The binding affinity of lactoferrin conjugated to the surface of iron oxide nanoparticles was determined by the AssayMax Human Lactoferrin ELISA Kit (Assaypro) according to the …

    The dominant expression of functional human lactoferrin in transgenic cloned goats using a hybrid lactoferrin expression construct

    Correlation between the concentrations of lactoferrin and neutrophil gelatinase-associated lipocalin in meconium

    • https://link.springer.com/article/10.1007/s10534-017-0073-3
    • B Lisowska-Myjak, E Skarżyńska, P Wilczyńska… - Biometals, 2018 - Springer
    • Neutrophil gelatinase-associated lipocalin (NGAL) and lactoferrin (Lf) are among the key components of the innate immune system due to their ability to bind iron with high affinity and …

    Development of transgenic goat embryos expressing human lactoferrin gene

    Urine lactoferrin as a potential biomarker reflecting the degree of malignancy in urothelial carcinoma of the bladder

    Lactoferrin levels in human breast milk among lactating mothers with sick and healthy babies in Kaduna State, Nigeria

    Study on the therapeutic benefit on lactoferrin in patients with colorectal cancer receiving chemotherapy

    • https://onlinelibrary.wiley.com/doi/abs/10.1155/2014/184278
    • TM Moastafa, AEDE El-Sissy… - International …, 2014 - Wiley Online Library
    • … change of the remaining parameters after than before treatment among the studied patients with colorectal cancer receiving chemotherapy (treated with recombinant human lactoferrin …

    Correlations between ceruloplasmin, lactoferrin and myeloperoxidase in meconium

    High‐temperature short‐time pasteurisation of human breastmilk is efficient in retaining protein and reducing the bacterial count

    • https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.13768
    • D Klotz, M Joellenbeck, K Winkler, M Kunze… - Acta …, 2017 - Wiley Online Library
    • … Lactoferrin and lysozyme content were assessed using the combined AssayMax Human Lactoferrin and Human Lysozym sandwich enzyme-linked immunosorbent assay kit (AssayPro, …

    Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage

    The high-level expression of human tissue plasminogen activator in the milk of transgenic mice with hybrid gene locus strategy

    • https://link.springer.com/article/10.1007/s12033-011-9428-0
    • Y Zhou, Y Lin, X Wu, F Xiong, Y Lv, T Zheng… - Molecular …, 2012 - Springer
    • … locus strategy, which was originally tested with human lactoferrin (hLF) as target transgene, and … The ELISA kits for the htPA antigen assay and activity assay both from AssayPro (cat no: …

    Effect of lactoferrin on pediatric infections

    • https://lirias.kuleuven.be/3009694?
    • T Ochoa, J Jacobs, V Cossey - 2020 - lirias.kuleuven.be
    • … human lactoferrin. Some examples are talactoferrin, a recombinant human lactoferrin … with sepsis69,70; a recombinant human lactoferrin produced in rice71 also tested in a trial …

    Relationships between meconium concentrations of acute phase proteins

    • https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.12995
    • B Lisowska‐Myjak, E Skarżyńska… - Clinical and …, 2018 - Wiley Online Library
    • Meconium concentrations of naturally accumulated ceruloplasmin (CER), lactoferrin (LF), and neutrophil gelatinase‐associated lipocalin (NGAL) and their relationships considered as a …

    Studies on the interaction between IgA, lactoferrin and lysozyme in the breastmilk of lactating women with sick and healthy babies

    The role of fecal calprotectin and lactoferrin in the diagnosis of necrotizing enterocolitis

    The effect of nasal irrigation formulation on the antimicrobial activity of nasal secretions

    • https://onlinelibrary.wiley.com/doi/abs/10.1002/alr.21604
    • CM Woods, S Tan, S Ullah… - … Forum of Allergy & …, 2015 - Wiley Online Library
    • Background Saline‐based irrigation solutions are evidence‐based rhinological treatments; however, the formulation of these solutions could theoretically alter the function of innate …

    Meconium lactoferrin levels in neonates: can we predefine normal values?

    • https://www.tandfonline.com/doi/abs/10.3109/14767058.2016.1171307
    • E Skarżyńska, J Żytyńska-Daniluk… - The Journal of …, 2017 - Taylor & Francis
    • Background and aims: In recent years, Lactoferrin (LF) has become an object of interest to neonatologists. To date, there have been no studies on the presence of LF in neonatal …

    Establishing human lacrimal gland cultures with secretory function

    Oxidant and antioxidant status of human breast milk during lactation period

    • https://link.springer.com/article/10.1007/s13594-015-0211-z
    • S Yuksel, AA Yigit, M Cinar, N Atmaca… - Dairy science & …, 2015 - Springer
    • Due to the oxidative stress conditions at birth, newborn needs some immunological and antioxidative protection after birth. The present study was conducted to point out the oxidant and …

    Effects of long-term supplementation of bovine colostrum on iron homeostasis, oxidative stress, and inflammation in female athletes: a placebo-controlled …

    • https://www.mdpi.com/2072-6643/15/1/186
    • M Cieślicka, J Ostapiuk-Karolczuk, HS Buttar… - Nutrients, 2022 - mdpi.com
    • Bovine colostrum supplementation has been suggested as a potential factor in reducing oxidative stress and inflammation. The primary objective of this study was to evaluate the effects …

    Effects of heat-not-burn cigarette smoking on the secretion of saliva and its innate immune system components

    • https://www.mdpi.com/2227-9032/11/1/132
    • Y Mori, M Tanaka, H Kozai, Y Aoyama, Y Shigeno… - Healthcare, 2022 - mdpi.com
    • Saliva and salivary antimicrobial proteins play important roles in the innate immunity, which prevents infections of orally invading bacteria and viruses. In this study, we compared the …

    Complement C5a functions as a master switch for the pH balance in neutrophils exerting fundamental immunometabolic effects

    • no link
    • S Denk, MD Neher… - The Journal of …, 2017 - American Association of …
    • no snippet

    Concentrations of neutrophil-derived proteins in meconium and their correlations

    • https://www.tandfonline.com/doi/abs/10.2217/bmm-2016-0034
    • B Lisowska-Myjak, J Żytyńska-Daniluk… - Biomarkers in …, 2016 - Taylor & Francis
    • Aim The aim was to measure concentrations of four neutrophil-derived proteins in meconium as biomarkers describing prenatal environment. Methods Calprotectin, lactoferrin, …

    Point-of-care human milk concentration by passive osmosis: comprehensive analysis of fresh human milk samples

    • https://www.nature.com/articles/s41372-024-01988-2
    • ER Schinkel, ER Nelson, JH Kim, MT Perrin… - Journal of …, 2024 - nature.com
    • Objective Preterm infants need enrichment of human milk (HM) for optimal growth. This study evaluated a novel, point-of-care human milk concentration (HMC) process for water …

    Plasma lactoferrin levels positively correlate with insulin resistance despite an inverse association with total adiposity in lean and severely obese patients

    Promotion of Hypercoagulability in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by C5a‐Induced Tissue Factor–Expressing Microparticles and …

    Lipopolysaccharide-Deficient Acinetobacter baumannii Due to Colistin Resistance Is Killed by Neutrophil-Produced Lysozyme

    Breast milk in neonate oral care: oropharyngeal effects in extremely preterm infants

    • https://link.springer.com/article/10.1007/s00431-022-04692-5
    • N Bourgeois-Nicolaos, A Raynor… - European Journal of …, 2023 - Springer
    • … LF concentrations were measured with a specific human ELISA Kit (Assaypro, Saint Charles-MI, USA) already used to measure LF in saliva [19] and milk [20]. In addition to the assays …

    Gene expression of renal lactoferrin and glycemic homeostasis in diabetic rats with reference to the protective role of exogenous bovine lactoferrin

    • https://link.springer.com/article/10.1186/s41936-020-00152-4
    • SH Qari, K Attia - The Journal of Basic and Applied Zoology, 2020 - Springer
    • Background This study is intended to clarify the influence of exogenous bovine lactoferrin (bLf) treatment on glycemic homeostasis, gene expression, and production of lactoferrin (Lf) in …

    Links between vitamin D-binding protein, alpha-1 antitrypsin and neutrophil proteins in meconium

    Influence of general cooling on the formation of adaptive reactions depending on the background level of lymphocytes with markers of early activation

    • https://link.springer.com/article/10.1134/S1062359024610036
    • VP Patrakeeva, EV Kontievskaya - Biology Bulletin, 2025 - Springer
    • A study of the peculiarities of the formation of adaptive reactions in response to short-term general cooling in practically healthy individuals, depending on the background level of …

    A method to induce high expression of human lysozyme in the milk of transgenic mice

    • https://e-century.us/files/ijcem/11/9/ijcem0067434.pdf
    • Y Zheng, G Wang, J Zhang - Int J Clin Exp Med, 2018 - e-century.us
    • Objective: To investigate a low cost and efficient method to induce high expression of human lysozyme (hLYZ) in milk. Methods: a hybrid gene locus strategy was applied in this study, to …

    Correlation Between Salivary Anxiety Markers and Salivary Biochemical Markers in Children with Primary and Mixed Dentition

    • https://dergipark.org.tr/en/pub/experimed/issue/50966/664869
    • S Oktay, S Demirel, ÜV Üstündağ, B Korkmaz… - Experimed, 2019 - dergipark.org.tr
    • DOI: 10.26650/experimed.2019.19021Objective: Anxiety due to the dentist and dental treatment is a problem encountered in many children. The aim of the present study is to determine …

    Development of organotypic human breast cell cultures for high throughput testing

    • https://scholarworks.calstate.edu/downloads/0c483k034
    • A Agarwal - 2014 - scholarworks.calstate.edu
    • Breast cancer is not a disease of individual cells, but a collective failure of cells and tissues to communicate properly. Malignant transformation of breast cells is a complex multi-stage …

    電子レンジ処理による母乳の成分変化に関する検討

    • https://showa.repo.nii.ac.jp/record/3740/files/ko3225_fulltext.pdf
    • 山本和也 - 2021 - showa.repo.nii.ac.jp
    • 1 背景: 超早産児では疾病予防効果も鑑み母乳栄養が推奨される一方, 母乳はサイトメガロウ 2 イルス (CMV) など感染性もある. 経母乳感染対策の標準はパスツール低温殺菌 (Holder 3 …

    Can aminopeptidase N determined in the meconium be a candidate for biomarker of fetal intrauterine environment?

    • https://www.sciencedirect.com/science/article/pii/S0014480020300125
    • B Lisowska-Myjak, P Wilczyńska, Z Bartoszewicz… - Experimental and …, 2020 - Elsevier
    • Aim To investigate possible association of aminopeptidase N/CD13 with other parameters of possible homeostatic mechanisms in meconium for potential use in identifying intrauterine …

    Impact of lipid degradation and tear film stability on silicone hydrogel contact lens wearers with discomfort

    • https://www.sciencedirect.com/science/article/pii/S1367048426000123
    • T Itokawa, T Suzuki, K Kakisu, Y Hori - Contact Lens and Anterior Eye, 2025 - Elsevier
    • Purpose To investigate the potential impact of lipid degradation deposition and tear film stability on contact lens discomfort in silicone hydrogel soft contact lens (SCL) wearers. Methods …

    Зв'язок показників лактоферину з молекулярно-біологічними особливостями злоякісних новоутворень молочної залози

    • https://nasu-periodicals.org.ua/index.php/oncology/article/view/26202
    • СО Собченко, НЮ Лук'янова, ВМ Базась… - …, 2021 - nasu-periodicals.org.ua
    • … го біохімічного та імуноферментного аналізатора Chem Well 2900 згідно з введеною програмою прото колу до наборів Human Lactoferrin AssayMax ELISA Kit (AssayPro, USA). …

    of September 10, 2020. This information is current as

    Large-scale production of functional human lysozyme in transgenic cloned goats

    • https://www.sciencedirect.com/science/article/pii/S0168165613004562
    • H Yu, J Chen, S Liu, A Zhang, X Xu, X Wang, P Lu… - Journal of …, 2013 - Elsevier
    • Human lysozyme (hLZ), an essential protein against many types of microorganisms, has been expressed in transgenic livestock to improve their health status and milk quality. However, …

    ANALYTICAL PERFORMANCE OF NOVEL ASSAY FOR MEASURING SEX HORMONE-BINDING GLOBULIN (SHBG) USING FLUORESCENCE IMMUNOASSAY BY …

    The development of transgenic mice for the expression of large amounts of human lysozyme in milk

    • https://link.springer.com/article/10.1007/s10529-014-1476-7
    • X Wu, Y Lin, Y Xi, Z Shao, Y Zhou, F Liu, H Chen - Biotechnology letters, 2014 - Springer
    • Human lysozyme (hLYZ) has important potential applications as antimicrobial medicine and food additive. To develop a robust expression vector that ensures expression of large …

    小児における唾液中抗菌物質の動態と生活習慣との関連

    • https://kdu.repo.nii.ac.jp/record/955/files/kou489_summary.pdf
    • 井出桃, イデモモ - 2016 - kdu.repo.nii.ac.jp
    • 成人で 1 日に約 1.0~ 1.5 ℓ 分泌される唾液は, 口腔内を湿潤状態に保ち, 咀嚼, 会話などの口腔 機能に重要な役割を果たしている. また唾液には洗浄作用, 再石灰化作用, 緩衝作用, 消化作用, 抗菌…

    Mechanisms and Acquisition of Antibiotic Resistance in N. gonorrhoeae

    Comprendre les réponses aberrantes des neutrophiles dans le lupus pour le développement de nouvelles approches thérapeutiques

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