Human Protein C

Two novel compound heterozygous mutations associated with types I and II protein C deficiency with unusual phenotypes

• https://www.sciencedirect.com/science/article/pii/S0049384816305023
• M Deng, Z Liu, H Huang, Y Chen, Y Luo, N Sun… - Thrombosis …, 2016 - Elsevier
• … Plasma PC antigen levels were determined using an enzyme-linked immunosorbent assay (Human Protein C ELISA Kit, Assaypro, USA), following the manufacturer's instructions. …

Potential value of human thrombomodulin and DAF expression for coagulation control in pig‐to‐human xenotransplantation

• https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-3089.2009.00555.x
• Y Miwa, K Yamamoto, A Onishi, M Iwamoto… - …, 2010 - Wiley Online Library
• … Another candidate for molecular incompatibility, porcine thrombomodulin (TM), can bind human thrombin, but cannot effectively convert human protein C into activated protein C (APC) […

Supplementary research on K150del variant of activated protein C

• https://pmc.ncbi.nlm.nih.gov/articles/PMC8148483/
• WY Lin, L Tang, X Lu, Y Hu - Aging (Albany NY), 2021 - pmc.ncbi.nlm.nih.gov
• … Antigen concentrations of APC-WT and APC-DEL were detected by Human Protein C ELISA Kit and were adjusted to consistent levels (10–100 nM) by PBS. The anticoagulant activity …

Production of cloned pigs expressing human thrombomodulin in endothelial cells

• https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-3089.2012.00696.x
• S Yazaki, M Iwamoto, A Onishi, Y Miwa… - …, 2012 - Wiley Online Library
• … As a cofactor, pig thrombomodulin was reported to be unable to efficiently convert human protein C into activated protein C that exhibits anticoagulant activity through inactivation of …

Intraovarian thrombin and activated protein C signaling system regulates steroidogenesis during the periovulatory period

• https://academic.oup.com/mend/article-abstract/26/2/331/2614908
• Y Cheng, K Kawamura, M Deguchi… - Molecular …, 2012 - academic.oup.com
• … Extracted proteins were used to measure prothrombin and APC levels using ELISA kits for prothrombin (Assaypro, St. Charles, MO) and mouse APC (USCN Life Science, Wuhan, China)…

CRISPR/Cas and recombinase-based human-to-pig orthotopic gene exchange for xenotransplantation

• https://www.sciencedirect.com/science/article/pii/S0022480418302129
• RMN Dos Santos, LAC D'albuquerque… - Journal of Surgical …, 2018 - Elsevier
• Background Tools for genome editing in pigs are improving rapidly so that making precise cuts in DNA for the purposes of deleting genes is straightforward. Development of means to …

Exploring Biomarkers to Predict Thrombogenic Risk in Pregnancy

• https://www.mdpi.com/2077-0383/14/3/932
• C Filip, DR Matasariu, A Ursache, CD Dimitriu… - Journal of Clinical …, 2025 - mdpi.com
• … products (FDPs): APL, APOH, and human protein C (PROC) from My BioSource, human factor V (factor V) from AssayPro, and human protein S (PROS1) from Novus Biologicals. …

Functional difference between membrane-bound and soluble human thrombomodulin

• https://journals.lww.com/transplantjournal/FullText/2015/04000/Functional_Difference_Between_Membrane_bound_and.13.aspx
• Y Miwa, S Yazaki, M Iwamoto, S Suzuki… - …, 2015 - journals.lww.com
• Background For successful xenotransplantation, in addition to α1, 3-galactosyltransferase gene-knockout and human complement regulatory protein (CD46, CD55, CD59) gene …

Analysis of the genetic variants associated with recurrent thromboembolism in a patient with hemoglobin H disease following splenectomy: A case report

• https://www.spandidos-publications.com/10.3892/br.2016.674?text=abstract
• NA Sun, P Cheng, DH Deng, RR Liu… - Biomedical …, 2016 - spandidos-publications.com
• … PC and PS antigens were measured by an enzyme-linked immunosorbent assay using the Human Protein C ELISA kit (AssayPro, St. Charles, MO, USA) and Zymutest Protein S ELISA …

Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury

• https://pmc.ncbi.nlm.nih.gov/articles/PMC5240667/
• R Carnemolla, CH Villa, CF Greineder… - The FASEB …, 2016 - pmc.ncbi.nlm.nih.gov
• … of APC generation in a manner specific to this experimental setup, in which the assay reflects APC generation after administration of exogenous thrombin and human protein C and not …

Childhood asthma is associated with polymorphic markers of PROC on 2q14 in addition to 17q21 locus

• https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.12336
• WC Chan, HY Sy, APS Kong, CK Wong… - Pediatric Allergy and …, 2015 - Wiley Online Library
• Background Childhood asthma is caused by both genetic and environmental factors. The first genomewide association study ( GWAS ) for asthma revealed putative candidates on nine …

A method to induce high expression of human lysozyme in the milk of transgenic mice

• https://e-century.us/files/ijcem/11/9/ijcem0067434.pdf
• Y Zheng, G Wang, J Zhang - Int J Clin Exp Med, 2018 - e-century.us
• … Furthermore, human protein C was expressed in the milk of transgenic pigs and reached … ELISA kit (milk) (Assaypro, Brooklyn, NY) was used according to the manufacturer’s protocol. …

Substituição gênica ortotópica de porco para humano baseada em CRISPR/Cas9 e recombinases para xenotransplante

• https://www.teses.usp.br/teses/disponiveis/5/5168/tde-14112017-153947/en.php
• RMN Santos - 2017 - teses.usp.br
• … However, in spite of the fact that both pig and human thrombomodulin can bind human protein C, only the latter complex can activate human protein C (84). This explains at least part of …